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    Artwork for Astral Codex Ten Podcast
    Episode

    The Quest For Caffeine You Can Have At Night

    Astral Codex Ten Podcast · Sep 5, 2026 · 26 min
    Episode page

    Since the beginning of time, mankind has yearned to drink a cup of coffee at 5 PM and go to sleep at 10. But now there's an entire scientific subfield and several companies pandering to this absurd fantasy. Here's a simplified diagram of caffeine metabolism: Caffeine is converted to a different stimulating chemical called paraxanthine by a liver enzyme called CYP1A2, over a half-life of ~5…

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