Stats for nerds
2recommend
3mentions
2people
2010–2012years
100% recommend
Mentions per year
What Hacker News says
- First of all, the distinction needs to be made between type 1 and type 2, these are two different things.
If you respect Ray Kurzweil's ideas, which I think a fair number of people here do, then I would suggest anyone with diabetes concerns (at risk, got it, etc) read his book "Transcend."
Direct quote:
"Largely because of excessive consumption of simple carbohydrates and sugary foods, the number of people with type 2 diabetes in the United States has increased tenfold in the past 35 years, and as of 2008, type 2 diabetes affected over 21 million Americans. In just the 10 years between 1997 and 2007, the incidence of type 2 diabetes nearly doubled in the United States, from 4.8 to 9.1 per 1,000 people."
The reason why Paleo is recommended is because high glycemic index carbohydrates are virtually eliminated. That certainly is not the only diet that accomplishes this. In Transcend, a low calorie somewhat Japanese diet is encouraged. That is something that is extremely difficult, behaviorally, for Westerners to strictly adapt. In my own experience it took about 3-4 years of behavior modification to do that, and I ended up medically underweight. "Paleo", at least for males from what I've seen, is fairly easy.
If you disagree with Kurzweil, well then I can't say much else, he certainly knows more about this than I do.
- In my opinion conquering aging is pretty much the same a beating any other disease albeit aging is a complex issue involving many different processes. What is comes down to is the realization that there is no magic bullet and that it is a case of chipping away at the root causes and making progress incrementally until we have them all brought to a position where they are manageable. Aging is no different to any other process and we are starting to understand the root causes and the changes which arise as the body ages. I agree that Aubrey makes it sound simpler than it actually is by breaking the causes down to seven factors as set out below but that does not mean that it is not a realistic proposition to render aging a treatable although chronic condition within 25 to 30 years! The key is funding and for more on that check out http://www.methuselahfoundation.org/
As Aubrey points out we have already discovered the seven biochemical processes which are the root cause of aging. The first was discovered in the mid 1950s, the last almost 30 years ago in 1981. The importance of the amount of time that has elapsed since the discovery of the last of the seven is that it took less time to discover the entire list than has passed since and nothing else has been found. Now factor in the massive increase in our knowledge of biology that has taken place over that time and it seems virtually certain that these seven causes are all there are - cure those and you cure aging! The following is the list with potential solutions some of which are either confirmed or where progress is already at an advanced stage.
1. Cell death and atrophy: Treatable with exercise, stem cells, and chemicals which stimulate cell division.
2. Cancerous cells: Theoretically treatable with a type of gene therapy being developed, called Whole Body Interdiction of Lengthening of Telomeres (WILT).
3. Mutant mitochondria: Mutated DNA in the mitochondria causes a number of diseases. These can be prevented by moving the mitochondrial DNA into the cell nucleus, where the rest of the DNA resides.
4. Cell senescence (unwanted cells): Fat cells and other unwanted cruft can be removed surgically, or by stimulating the immune system to attack unwanted cells.
5. Extracellular crosslinks (loss of elasticity): Certain proteins, such as those in cells making up the arteries, become too rigid over time because they bond to each other. These bonds can be broken with certain chemicals (some in clinical trials even today).
6 Extracellular junk: “Plaque” which collects between cells can be eliminated by stimulating the immune system, and/or by using peptides called “beta-breakers.”
7. Intracellular junk: Molecular garbage can be prevented from overwhelming certain cells by introducing enzymes which are known to be effective against such molecules.
In my opinion aging is no different to any other disease and like all diseases aging is ultimately treatable given the requisite technology. We cannot afford to sit back and simply accept that because everyone in history has lived and died we must follow the same patch. It is a mistake to view aging as a fact of life set in stone when science has progressed to the level where we have the ability to begin the search for a cure. We might not be there yet but we are within striking distance of adding 20 or 30 years to our life expectancy and as Aubrey himself points out increases in life expectancy will be incremental and there is not going to be a sudden magic pill which you take and live forever. The essence of the engineering approach advocated by Aubrey is to manage aging, what he proposes is not a cure but a case of repairing the damage that occurs as we age at various intervals and not to stop the process but to allow the aging process to continue and repair the damage as it arises in the same way you maintain a house or car. This engineering approach is a case of taking advantage of improvements in technology as they occur and not to attempt to cure aging in its entirety and it is in this area that people fail to grasp what Aubrey de Grey is seeking to achieve. I recommend the two books below as great reading and all will be revealed!
Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (Aubrey de Grey and Michael Rae) ISBN-10: 0312367066 ISBN-13: 978-0312367060
Transcend: Nine Steps to Living Well Forever (Ray Kurzweil and Terry Grossman MD) ISBN-10: 1605299561
I would also check out the following regarding Aubrey de Grey http://www.citywire.co.uk/personal/-/retirement/news-and-fea...
and also the following about Ray Kurzweil if this lot does not wet your appetite for joining the war on aging nothing will!
- In some areas we are making rapid progress on some rather less but solutions are know to all 7 causes of aging as outlined below.
1. Cell death and atrophy: Treatable with exercise, stem cells, and chemicals which stimulate cell division.
2. Cancerous cells: Theoretically treatable with a type of gene therapy being developed, called Whole Body Interdiction of Lengthening of Telomeres (WILT).
3. Mutant mitochondria: Mutated DNA in the mitochondria causes a number of diseases. These can be prevented by moving the mitochondrial DNA into the cell nucleus, where the rest of the DNA resides.
4. Death Resistant Cells or Cell senescence (unwanted cells): Fat cells and other unwanted cruft can be removed surgically, or by stimulating the immune system to attack unwanted cells.
5. Tissue stiffening or Extracellular crosslinks (loss of elasticity): Certain proteins, such as those in cells making up the arteries, become too rigid over time because they bond to each other. These bonds can be broken with certain chemicals (some in clinical trials even today).
6 Extracellular aggregates or junk: “Plaque” which collects between cells can be eliminated by stimulating the immune system, and/or by using peptides called “beta-breakers.”
7. Intracellular aggregates or junk: Molecular garbage can be prevented from overwhelming certain cells by introducing enzymes which are known to be effective against such molecules.
In my opinion aging is no different to any other disease and like all diseases aging is ultimately treatable given the requisite technology. We cannot afford to sit back and simply accept that because everyone in history has lived and died we must follow the same path. It is a mistake to view aging as a fact of life set in stone when science has progressed to the level where we have the ability to begin the search for a cure. We might not be there yet but we are within striking distance of adding 20 or 30 years to our life expectancy and as Aubrey himself points out increases in life expectancy will be incremental and there is not going to be a sudden magic pill which you take and live forever. The essence of the engineering approach advocated by Aubrey is to manage aging, what he proposes is not a cure but a case of repairing the damage that occurs as we age at various intervals and not to stop the process but to allow the aging process to continue and repair the damage as it arises in the same way you maintain a house or car. This engineering approach is a case of taking advantage of improvements in technology as they occur and not to attempt to cure aging in its entirety and it is in this area that people fail to grasp what Aubrey de Grey is seeking to achieve. I recommend the two books below as great reading and all will be revealed!
Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (Aubrey de Grey and Michael Rae) ISBN-10: 0312367066 ISBN-13: 978-0312367060
Transcend: Nine Steps to Living Well Forever (Ray Kurzweil and Terry Grossman MD) ISBN-10: 1605299561
I would also check out the following regarding Aubrey de Grey http://www.citywire.co.uk/personal/-/retirement/news-and-fea...
and also the following about Ray Kurzweil if this lot does not wet your appetite for joining the war on aging nothing will!
