
Escaping from the World Trade Center during the September 11 attacks, Keith Neudecker makes his way to the uptown apartment where his ex-wife and young son are living and considers how the day's events have irrevocably changed his perception of the world.
If you are asking about books from any period of his output, then White Noise can be recommended, I personally see it as his greatest achievement. Underworld gets a lot of hype due to its sheer length but I don’t find it particularly impressive or moving.
I've been trying to get through Ratner's Star for years. It's not bad but I suppose it's just not the most compelling.
Delillo and Cormac McCarthy are two current authors I would expect to be read 100 years from now.
This is exactly how I feel about characters in novels. It reminds me of Nabakov, who famously ended a lecture with:
> In this course I have tried to reveal the mechanism of those wonderful toys — literary masterpieces. I have tried to make of you good readers who read books not for the infantile purpose of identifying oneself with the characters, and not for the adolescent purpose of learning to live, and not for the academic purpose of indulging in generalizations. I have tried to teach you to read books for the sake of their form, their visions, their art. I have tried to teach you to feel a shiver of artistic satisfaction, to share not the emotions of the people in the book but the emotions of its author — the joys and difficulties of creation. We did not talk around books, about books; we went to the center of this or that masterpiece, to the live heart of the matter
I think that's basically right: the best way to read a novel is as a dialogue with the author.
DeLillo is the only example of an American who has written about recent history and contemporary American life in a way that resonants with me: unmistakably American, involved, but also detached. He's written about everything from foreign policy (The Names), to academia (White Noise, Ratner's Star), to JFK's assassination (Libra), to the Cold War (Underworld), to finance (Cosmopolis), to 9/11 (Falling Man), to the Iraq War (Point Omega), to start-up culture and worship of technology (Zero K).