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    Artwork for Talk Python To Me
    Episode

    #519: Data Science Cloud Lessons at Scale

    Talk Python To Me · Sep 18, 2025 · 1 h 03 min
    Episode page

    Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat Tabris a staff software engineer at Coiled join me to unpack the messy truth of cloud-scale Python. During the episode we actually spin up a 1,000 core cluster from a notebook, twice! We also discuss picking between pandas and Polars, when GPUs…

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