Episode
Evolution designed us to die fast; we can change that — Jacob Kimmel
Dwarkesh Podcast · Aug 21, 2025 · 1 h 45 min
Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene…