
The revolutionary animal cyborg prototypes, a dog, a cat and a rabbit code-named We3, created as weapons but not liking that fact, escape and head out into a frightening world to fight for their own survival.
Others off the top of my head:
Wizzywig by Ed Piskor - fictional account of a Kevin Mitnick-type hacker.
We3 by Grant Morrison and Frank Quitely - 3 bionically enhanced animals escape their captors and talk funny.
Lazarus by Greg Rucka and Michael Lark - an immortal hitwoman with a conscience in a feudal society.
RASL by Jeff Smith - art thief is chased through parallel universes.
Casanova by Matt Fraction, Fabio Moon and Gabriel Ba - more parallel universe hijinks, this time with spies.