
A self-satisfied couple intent on raising a happy family is shocked by the birth of an abnormal and brutal fifth child.
E.L. Doctorow is another such example. Try The Book of Daniel, Ragtime, Billy Bathgate, Loon Lake.
In the scifi genre (aside from the Shikasta series already mentioned), M. John Harrison is worth a look. He’s got a long bibliography but Light might be a good starting point.
Umberto Eco: The Name of the Rose, Foucault’s Pendulum.
Some of Ursula Le Guin’s more serious books might fit the bill, like The Dispossessed or The Left Hand of Darkness.
Someone already mentioned Mervyn Peake, he definitely fits this category.
And now in this article an autist is described as a warty monster from a Grimm fairy tale, and I suddenly understand what this novel is about. I am a little shocked to see an autist portrayed as a troll in a horror story.
