Molecular Neuropharmacology

What Hacker News says

1. Bucephalus355Dec 2018
   This is very important. It’s not yet fully understood, but something is missing yet in our understanding of inflammation.

   It’s not everything, just like antibiotics weren’t everything, but progress here will mean curing an incredible amount of human suffering.

   The book linked below, a late 2015 text on Molecular Neuropharmacology, is fascinating. Every chapter has a mention of inflammation and usually ibuprofen. It’s that important.

   Particularly fascinating is the connection with ADHD, Parkinson’s, and Schizophrenia. All of the diseases have something to do with dysregulation of Dopamine. In particular, it seems like Ibuprofen helps with reducing the effects of Dopamine overload, which is essentially what Schizophrenia is. It’s an inflammation of the mind that is somewhat similar to how we now think sugar causes harm/inflammation. Anyway this overload eventually can lead to underload, or Parkinson’s. ADHD individuals are often overloaded as well due to the treatment with stimulant medication (which is good but can be abused).

   I’m not kidding when I say there are Nobel prizes being left on the table here right now.

   https://www.amazon.com/Molecular-Neuropharmacology-Foundatio...

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2. kragenMay 2022
   Jesus fuck.

   Spencer RC, Devilbiss DM, Berridge CW (June 2015). "The Cognition-Enhancing Effects of Psychostimulants Involve Direct Action in the Prefrontal Cortex". Biological Psychiatry. 77 (11): 940–950. doi:10.1016/j.biopsych.2014.09.013. PMC 4377121. PMID 25499957.

   Ilieva IP, Hook CJ, Farah MJ (June 2015). "Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis". Journal of Cognitive Neuroscience. 27 (6): 1069–1089. doi:10.1162/jocn_a_00776. PMID 25591060. S2CID 15788121.

   Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 13: Higher Cognitive Function and Behavioral Control". In Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York, USA: McGraw-Hill Medical. pp. 318, 321. ISBN 9780071481274

   Bagot KS, Kaminer Y (April 2014). "Efficacy of stimulants for cognitive enhancement in non-attention deficit hyperactivity disorder youth: a systematic review". Addiction. 109 (4): 547–557. doi:10.1111/add.12460. PMC 4471173. PMID 24749160.

   Wood S, Sage JR, Shuman T, Anagnostaras SG (January 2014). "Psychostimulants and cognition: a continuum of behavioral and cognitive activation". Pharmacological Reviews. 66 (1): 193–221. doi:10.1124/pr.112.007054. PMC 3880463. PMID 24344115.

   Teter CJ, McCabe SE, LaGrange K, Cranford JA, Boyd CJ (October 2006). "Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration". Pharmacotherapy. 26 (10): 1501–1510. doi:10.1592/phco.26.10.1501. PMC 1794223. PMID 16999660.

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